Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases

A compound of the formula

• wherein
• m is 2 or 3;
• n is 0 or 1;
• q is 1 or 2;
• r is 0 or 1;
• G1 is —CH2— or —C(O)—;
• G2 is —CH2—, —CH(CH3)— or —C(O)—;
• G3 is —CH2— or C(O)—;
• Ar1 is a radical chosen from the group consisting of
• wherein
• R1 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, hydroxy, —CF3, C1-C6 alkyl, and C1-C6 alkoxy;
• R2 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy;
• Ar2 is a radical selected from the group consisting of
• wherein
• z is 1 or 2;
• R20 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, hydroxy, halogen, C1-C6 alkyl, and C1-C6 alkoxy;
• R3 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, hydroxy, halogen, —OCF3, C1-C6 alkyl, C1-C6 alkoxy, (CH2)dS(O)bR22, —(CH2)eCN, —O(CH2)cCO2R23, —NH2, —NHC(O)CH3, —NHSO2CH3 wherein c is an integer from 1 to 5;
• b is 0, 1, or 2;
• d is 0 or 1;
• e is 0 or 1;
• R22 is C1-C4 alkyl;
• and R23 is hydrogen or C1-C4 alkyl;
• R21 is hydrogen or a radical chosen from the group consisting of
• wherein
• f is 0 or 1;
• R25 is hydrogen or —CH3;
• R24 is selected from the group consisting of hydrogen, C1-C4 alkyl, —CF3, phenyl, S(O)xR26, and CH2N(CH3)2 wherein x is 0, 11 or 2;
• R26 is C1-C4 alkyl;
• X is a radical chosen from the group consisting of
• wherein
• R4 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, —CF3, C1-C6 alkyl, and C1-C6 alkoxy;
• R5 is chosen from the group consisting of hydrogen, C1-C4 alkyl, —(CH2)w—O—(CH2)tCO2R8, —(CH2)jCN, —(CH2)uCO2R6, —(CH2)uC(O)NR16R17, —(CH2)uC(O)(CH2)iCH3 —(CH2)pAr3, —(CH2)w—O—R7, —CH2CH═CHCF3, —(CH2)2CH═CH2, —CH2CH═CH2, —CH2CH═CHCH3, —CH2CH═CHCH2CH3, —CH2CH═C(CH3)2, and —(CH2)gS(O)kR19,
• wherein
• w is an integer from 2 to 5;
• t is an integer from 1 to 3;
• j is an integer from 1 to 5;
• u is an integer from 1 to 5;
• i is 0, 1, or 2;
• p is an integer from 1 to 5;
• g is 2 or 3;
• k is 0, 1, or 2;
• R8 is hydrogen or C1-C4 alkyl;
• R6 is hydrogen or C1-C4 alkyl;
• R16 is hydrogen or C1-C4 alkyl;
• R17 is hydrogen or C1-C4 alkyl;
• R19 is C1-C4 alkyl or a radical of the formula
• Ar3 is a radical chosen from the group consisting of
• wherein
• R9 is from 1 to 3 substituents each independently chosen from the group consisting of hydrogen, halogen, —CF3, C1-C6 alkyl, C1-C6 alkoxy, and —CO2R13 wherein R13 is chosen from the group consisting of hydrogen and C1-C4 alkyl;
• R10 is from 1 to 2 substituents each independently chosen from the group consisting of hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy;
• R11 is chosen from the group consisting of hydrogen, —CH3, and —CH2OH;
• R12 is chosen from the group consisting of hydrogen, C1-C4 alkyl, and benzyl;
• R18 is chosen from the group consisting of hydrogen, halogen, —CH3, and —CH2OH;
• R7 is hydrogen, C1-C4 alkyl, —(CH2)y—CF3, —CH2CN or a radical chosen from the group consisting of
• wherein
• v is an integer from 1 to 3;
• y is an integer from 0 to 2;
• R14 is chosen from the group consisting of hydrogen, halogen, C1-C4 alkyl, and —CO2R15 wherein R15 is hydrogen or C1-C4 alkyl;
• provided that when G1 is —C(O)— then G2 is either —CH2— or —CH(CH3)— and G3 is —CH2—;
• further provided that when G2 is —C(O)— then G1 is —CH2— and G3 is —CH2—;
• still further provided that when G3 is —C(O)— then G1 is —CH2— and G2 is either —CH2— or —CH(CH3)—;
• or stereoisomers, or pharmaceutically acceptable salts thereof.