CRF antagonistic thiophenopyridines

A compound of formula

• including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein
• X is S or SO2;
• R1 is C1-6alkyl;
• NR5R6, OR6 or SR6;
• R2 is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio;
• R3 is Ar1 or Het1;
• R4 is hydrogen or C1-6alkyl;
• R5 is hydrogen, C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxyC1-6alkyl;
• R6 is C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar2CH2, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl;
• or R5 and R6 taken together with the nitrogen atom to which they are attached may form a pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group, optionally substituted with C1-6alkyl or C1-6alkyloxyC1-6alkyl;
• and
• Ar1 is phenyl;
• phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino and mono- or di(C1-6alkyl)amino;
• Het1 is pyridinyl;
• pyridinyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, trifluoromethyl, hydroxy, cyano, C1-6alkyloxy, benzyloxy, C1-6alkylthio, nitro, amino, and mono- or di(C1-6alkyl)amino;
• and
• Ar2 is phenyl;
• phenyl substituted with 1, 2 or 3 substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, di(C1-6alkyl)aminoC1-6alkyl, or trifluoromethyl.