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US 6,211,193 B1Granted
Compounds useful for inhibition of farnesyl protein transferase
AssigneeSchering Corporation
InventorsStacy W. Remiszewski, Ronald J. Doll, Carmen Alvarez, Tarik Lalwani
Life of this patent
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Abstract
Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Claims16
A compound selected from:
A compound selected from compounds of the formula:
- wherein R21 is selected from the substituents listed in Table 2:
- TABLE 2 Compound R21 43.0 44.0 H 45.0 46.0 49.1
A compound selected from:
A compound selected from:
Dependencies are inferred from the claim text.