Cardiac diseases improving method

A method for treating cardiac disease, comprising the step of administering to a patient in need of treatment an effective amount of a compound having the following general formula (II) or pharmacologically acceptable salts thereof

• Chemical formula 2
• wherein R51 represents hydrogen atom, an alkyl group having 1-8 carbon atoms, a haloalkyl group having 1-8 carbon atoms, or —NR57R58;
• R52 represents —C(═O)— or single bond;
• R53 represents —OR59, a 3-7 membered saturated aliphatic cyclic amino group optionally interrupted with nitrogen atom, oxygen atom or sulfur atom, a 3-7 membered saturated aliphatic cyclic amino group containing at least one nitrogen atom and substituted with an alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring, or —NR60R61;
• R54 represents hydrogen atom, an alkyl group having 1-8 carbon atoms, a haloalkyl group having 1-8 carbon atoms, —(CH2)mNR62R63, —(CH2)nR64, —(CH2)pCH(NR65R66)COOR67, —R68—COOR69, —CH(R70)OC(═O)OR71, or —CH(R72)OC(═O)R73;
• R60 and R61 each independently represents hydrogen atom, an alkyl group having 1-8 carbon atoms, a haloalkyl group having 1-8 carbon atoms, or —(CH2)qNR74R75;
• R64 represents a 3-7 membered saturated aliphatic cyclic amino group optionally interrupted with nitrogen atom, oxygen atom or sulfur atom, a 3-7 membered saturated aliphatic cyclic amino group containing at least one nitrogen atom and substituted with an alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring, a 3-7 membered saturated aliphatic cyclic alkyl group containing at least one nitrogen atom and substituted with an alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring, or a 3-7 membered unsaturated heterocyclic group;
• R68 represents a 3-7 membered saturated aliphatic cyclic alkylene group containing at least one nitrogen atom and substituted with a alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring;
• R71 and R73 represent —(CH2)rR76;
• R76 represents hydrogen atom, an alkyl group having 1-8 carbon atoms, a haloalkyl group having 1-8 carbon atoms, —NR77R78, or a 3-8 membered saturated aliphatic cyclic alkyl group;
• Z represents C[, CH, or N];
• A represents CH or N;
• R55, R56, R57,R58,R59,R62,R63,R65, R66, R67, R69, R70, R72,R74, R75, R77 and R78 each independently represents hydrogen atom, an alkyl group having 1-8 carbon atoms, or a haloalkyl group having 1-8 carbon atoms;
• m, q and r each independently represents an integer of 1-6;
• n and p each independently represents 0 or an integer of 1-6, with a proviso when R54 represents hydrogen atom, an alkyl group having 1-8 carbon atoms, or a haloalkyl group having 1-8 carbon atoms, then R53 represents a 3-7 membered saturated aliphatic cyclic amino group containing at least one nitrogen atom and substituted with an alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring, a 3-7 membered saturated aliphatic cyclic alkyl group containing at least one nitrogen atom and substituted with an alkyl group having 1-8 carbon atoms or a haloalkyl group having 1-8 carbon atoms in the ring, or —NR60R61 wherein at least one of R60 and R61 represent —(CH2)qNR74R75.