Peptide conjugates derived from thymic hormones, their use as a medicament and compositions containing them
AssigneeInstitut European de Biologie Cellulaire
InventorsLucien Dussourd, Anne-Marie Pinel
Life of this patent
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Abstract
The invention relates to peptide conjugates comprising a sequence of at least 3 amino acids derived from a thymic hormone selected amongst thymuline and thymopoietine, the amino acids being independently in the form D, L or DL, said sequence being chemically or physically conjugated with at least one compound selected amongst monocarboxylic acids having the general formula (I): HOOC—R, as well as alcohol, aldehyde or amide derivatives, the dicarboxylic acids having the general formula (II): HOOC—R1—COOH. The invention also relates to the use of such conjugates as medicaments, and pharmaceutical or cosmetological compositions containing them.
Claims28
A method of correcting deficiencies of the immune system in a host animal, comprising topically administering to the host animal a therapeutically effective amount of a composition, comprising:
- (i) at least one peptide conjugate which includes a sequence of at least 3 amino acids, which are derived from a thymic hormone selected from the group consisting of thymulin and thymopoietin, wherein said sequence is conjugated with at least one compound which is selected from the group consisting of:
- (A) monocarboxylic acids of the general formula
- HOOC—R (I)
- in which R represents a straight-chain or branched, optionally substituted C1-C20 aliphatic radical, which can contain one or more unsaturations, or the alcohol, aldehyde, or amide derivatives of the acids of the formula I;
- and
- (B) dicarboxylic acids of the general formula
- HOOC—R1—COOH (II)
- in which R1 represents a straight-chain or branched divalent aliphatic radical comprising at least 3 carbon atoms, which can contain one or more unsaturations and can optionally be substituted;
- and
- (ii) a pharmaceutically or cosmetologically acceptable excipient that is suitable for topical administration.
Dependencies are inferred from the claim text.