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AssigneeSyntro Corporation
InventorsMark D. Cochran, Meng-Fu Shih, William P. MacConnell, Richard D. Macdonald
Estimating the term…
The present invention provides a hybrid, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the hybrid, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus and at least one foreign DNA sequence. Also provided is an attenuated, nonprimate herpesvirus comprising DNA which includes a sequence essential for viral replication of the attenuated, nonprimate herpesvirus, at least a portion of which is present in a sequence essential for replication of a naturally-occurring nonprimate herpesvirus, from which at least a portion of a repeat sequence has been deleted. Also provided are vaccines comprising the viruses of the invention and methods of immunizing animals against various disease.
A recombinant infectious bovine rhinotracheitis virus comprising a foreign DNA inserted into an infectious bovine rhinotracheitis virus genome, wherein the foreign DNA is inserted into a non-essential region of the infectious bovine rhinotracheitis virus genome and is expressed in a host cell into which the virus is introduced.
Dependencies are inferred from the claim text.