Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsWilliam G. Johnson, Edward Scott Stenroos
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Abstract
The present invention discloses a novel method for identifying an individual who may be susceptible to develop a developmental disorder. In one particular example, an individual is identified who is genetically susceptible to becoming schizophrenic. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with a developmental disorder. Methods of diagnosing, preventing and treating developmental disorders such as schizophrenia are also provided.
Claims23
An isolated nucleic acid encoding a human dihydiofolate reductase;
- said nucleic acid comprising a nucleotide sequence having a 19 base-pair deletion spanning nucleoides 540 to 558 of tie nucleotide sequence of SEQ ID NO:41.
A PCR primer comprising 10 nucleotides that can be used to distinguish SEQ ID NO:42 from a nucleotide sequence selected from the group consisting of SEQ ID NO:41 and SEQ ID NO:45.
A nucleic acid that hybridizes to the nucleotide sequence ACCTGGGCGGGACGCGCCA (SEQ ID NO:40) or a sequence complementary to SEQ ID NO:40;
- wherein said nucleic acid consists of 12 to 48 nucleotides;
- and wherein said nucleic acid does not hybridize to SEQ ID NO:42 or a sequence complementary to SEQ ID NO:42, when said hybridizing is performed under identical conditions.
A nucleotide probe comprising 1 nucleotides that hybridizes to the nucleotide sequence of SEQ ID NO:42, but not to the nucleotide sequence of SEQ ID NO:41, when said hybridizing is performed under identical conditions.
A nucleotide probe comprising 1 nucleotides that hybridizes to the complementary strand of the nucleotide sequence of SEQ ID NO:42, but not to the complementary strand of the nucleotide sequence of SEQ ID NO:41, when said hybridizing is performed under identical conditions.
A nucleotide probe comprising 1 nucleotides that hybridizes to the nucleotide sequence of SEQ ID NO:41, but not to the nucleoticle sequence of SEQ ID NO:42;
- when said hybridizing is performed under identical conditions.
A nucleotide probe comprising 1 nucleotides that hybridizes to the complementary strand of the nucleotide sequence of SEQ ID NO:41, but not to the complementary strand of the iiucleotide sequence of SEQ ID NO:42, when said hybridizing is performed under identical conditions.
A nucleic acid that hybridizes to the nucleotide sequence ACCTGGGCGGGACGCGCC (SEQ TD NO:46) or the complementary strand of SEQ ID NO:46;
- wherein said nucleic acid consists of 12 to 48 nucleotides;
- and wherein said nucleic acid does not hybridize to SEQ ID NO:42 or a sequence complementary to SEQ ID NO:42, when said hybridizing is perfozmed under identical conditions.
Dependencies are inferred from the claim text.