Anticoagulant test
AssigneeMerck & Co., Inc.
InventorsBohumil Bednar, Daniel M. Bollag, Robert J. Gould
Life of this patent
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Abstract
The present invention is a method for diagnosing a patient at risk to thrombocytopenia induced by administration of a GP IIb/IIIa receptor antagonist, which comprises combining i) a plasma sample of the patient; ii) detectable monoclonal antibody which recognizes induced binding sites formed on the GP IIb/IIIa receptor following association of a fibrinogen receptor antagonist with the GP IIb/IIIa receptor; and iii) GP IIb/IIIa receptor:GP IIb/III receptor antagonist complex, and determining association of the detectable monoclonal antibody with the complex in the presence of the plasma.
Claims6
A method for diagnosing a patient at risk to thrombocytopenia induced by administration of a glycoprotein IIb/IIIa receptor antagonist, by detecting the absence of association of a detectable monoclonal antibody with a glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex, which comprises combining
- i) a plasma sample of the patient;
- ii) the detectable monoclonal antibody, which is mAb10-758 or mAb15-758, which recognizes induced binding sites formed on the glycoprotein IIb/IIIa receptor following association of a glycoprotein IIb/IIIa receptor antagonist with the glycoprotein IIb/IIIa receptor;
- and
- iii) the glycoprotein IIB/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex,
- and detecting the absence of association of the detectable monoclonal antibody with the complex in the presence of the plasma.
A test kit for diagnosing a patient at risk to thrombocytopeniia induced by administration of a glycoprotein IIb/IIIa receptor antagonist, which comprises a glycoprotein IIb/IIIa receptor:glycoprotein IIb/III receptor antagonist complex, and a detectable monoclonal antibody which is mAb10-758 or mAb15-758 which recognizes induced binding sites formed on the glycoprotein IIb/IIIa receptor following association of a fibrinogen receptor antagonist with the glycoprotein IIb/IIIa receptor.
A method for identifying a patient not at risk to developing glycoprotein IIb/IIIa receptor antagonist-induced thrombocytopenia, by determining association of a detectable monoclonal antibody with a glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex, which comprises combining
- i) patient plasma;
- ii) the detectable monoclonal antibody, which is mAb10-758 or mAb15-758, which recognizes induced binding sites formed on the glycoprotein IIb/IIIa receptor following association of a glycoprotein IIb/IIIa receptor antagonist with the glycoprotein IIb/IIIa receptor;
- and
- iii) the glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex,
- to form a glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist:detectable monoclonal antibody complex, and detecting the presence of the detectable monoclonal antibody in the glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist:detectable monoclonal antibody complex.
A method for identifying a patient at risk to developing glycoprotein IIb/IIIa receptor antagonist-induced thrombocytopenia, by detecting the absence of association of a detectable monoclonal antibody with a glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex, which comprises combining
- i) patient plasma;
- ii) the detectable monoclonal antibody, which is mAb10-758 or mAb15-758, which recognizes induced binding sites formed on the glycoprotein IIb/IIIa receptor following association of a fibrinogen receptor antagonist with the glycoprotein IIb/IIIa receptor;
- and
- iii) the glycoprotein IIb/IIIa receptor:glycoprotein IIb/IIIa receptor antagonist complex,
- to form a mixture, and detecting the absence of the detectable monoclonal antibody in the mixture.
Dependencies are inferred from the claim text.