Alteration of cellular behavior by antisense modulation of mRNA processing
AssigneeIsis Pharmaceuticals, Inc.
InventorsC. Frank Bennett, Stanley T. Cooke, Muthiah Manoharan, Jacqueline R. Wyatt, Brenda F. Baker, Brett P. Monia, Susan M. Freier, Robert McKay, James G. Karras
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Abstract
The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.
Claims31
A method of modulation of processing of a selected wild-type cellular mRNA target, said method comprising binding to said target an antisense compound having at least one 2′-methoxyethoxy, 2′-dimethylaminooxyethoxy, 2′-dimethylaminoethoxyethoxy, 2′-acetamide, morpholino, or peptide nucleic acid modification which is specifically hybridizable with said mRNA target and which does not elicit cleavage of the mRNA target upon binding, so that processing of said mRNA target is modulated.
Dependencies are inferred from the claim text.