Asymmetric synthesis catalyzed by transition metal complexes with chiral ligands
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
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Abstract
This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.
Claims12
A method for synthesis of a chiral product in an enantiomeric excess from an organic substrate capable of being hydrogenated to said chiral product, comprising metal catalyzed asymmetric hydrogenation, wherein said asymmetric hydrogenation comprises the step of reacting said organic substrate with hydrogen in the presence of a catalyst, wherein said catalyst comprises a transition metal and a chiral ligand, and said chiral ligand comprises a 7-phosphabicyclo[2.2.1] heptyl compound.
Dependencies are inferred from the claim text.