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US 6,207,862 B1Granted
Precursors for the production of chiral 1,3-aminoalcohols
AssigneeBioCatalytics, Inc.
InventorJ. David Rozzell, Jr.
Life of this patent
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Abstract
The disclosure describes novel precursors for the preparation of chiral 1,3-aminoalcohols. The precursors are chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides produced from chiral gamma-lactones, which in turn are derived from 1,4-diols by stereoselective oxidation. The chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides are converted into chiral 1,3-aminoalcohols by stereospecific rearrangement.
Claims14
A compound represented by the formula
- wherein X is NH2 and R1 and R2 are independently chosen from the group consisting of hydrogen, alkenyl, cycloalkenyl, alkynyl, aryl, aralkenyl, and heterocyclic ring system, except that R1 and R2 are not both hydrogen, with the provisos that (1) when R1 is H, R2 is not phenyl or benzyl;
- and (2) when R2 is H, R1 is not benzyl.
A compound represented by the formula
- wherein:
- X is NH2;
- R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, alkynyl, aryl, aralkyl, aralkenyl, and heterocyclic ring system;
- and
- R2 is selected from the group consisting of hydrogen, alkenyl, cycloalkyl, cycloalkenyl, cycloalkenylalkyl, alkynyl, aryl, aralkyl, aralkenyl, and heterocyclic ring system;
- except that R1 and R2 are not both hydrogen, and with the provisos that (1) when R1 is H, R2 is not phenyl or benzyl;
- and (2) when R2 is H, R1 is not benzyl.
4 more elements
Dependencies are inferred from the claim text.