Stable no-delivering compounds
AssigneeDuke University Medical Center
InventorsEric J. Toone, Jonathan S. Stamler
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Abstract
Disclosed are novel NO-releasing compounds which comprise a stabilized S-nitrosyl group and a free alcohol or a free thiol group. Also disclosed is a method of preparing the NO-releasing compounds. The method comprises reacting a polythiol or a thioalcohol with a nitrosylating agent. Also disclosed are medical devices coated with the disclosed compounds, methods of delivering NO to treatments sites in a subject by utilizing the medical devices and methods of sterilizing surfaces.
Claims10
A compound represented by the following structural formula:
- wherein:
- R is an organic radical;
- each X′ is independently a substituted or unsubstituted aliphatic group;
- and
- p and m are each a positive integer such that p+m is greater than two and less than or equal to about 10.
A compound prepared by reacting a polythiol with a nitrosylating agent, wherein the polythiol is an esterified polyol represented by the following structural formula:
- wherein:
- R is an organic radical;
- n is a positive integer from three to about ten;
- and
- each X is independently a substituted or unsubstituted thiol-bearing aliphatic group.
A method of preparing a compound with a stabilized S-nitrosyl group, said method comprising the step of reacting a polythiol with a nitrosylating agent, wherein the polythiol is an esterified polyol represented by the following structural formula:
- wherein:
- R is an organic radical;
- n is a positive integer from three to about ten;
- and
- each X is independently a substituted or unsubstituted thiol-bearing aliphatic group.
Dependencies are inferred from the claim text.