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US 6,207,847 B1Granted
Manufacture of optically active halohydrin trialkylsilyl ethers
AssigneeE. I. Du Pont de Nemours and Company
InventorWilliam Aloysius Nugent, Jr.
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Abstract
A process for the production of optically active Si compounds by reacting a meso-epoxide with a azidotrimethylsilane and a hydrocarbyl halide in the presence of a catalyst formed from the sequential treatment of hafnium t-butoxide or zirconium t-butoxide with one equivalent of homochiral optically active triisopropanolamine, water, and a source of trifluoroacetae ion is disclosed.
Claims7
A process for the manufacture of optically active compounds comprising:
- reacting a meso-epoxide with azidotrimethylsilane and a compound of the formula R′X, where R′ is an optionally substituted hydrocarbyl and X is selected from the group consisting of Cl, Br and I;
- to produce a compound of the formula (1)
- wherein:
- R is optionally substituted hydrocarbyl, or both together can form a ring;
- in the presence of a catalytic amount of a catalyst formed from the sequential treatment of hafnium t-butoxide or zirconium t-butoxide with one equivalent of homochiral optically active triisopropanolamine, water and a source of trifluoroacetate ion.
2 more elements
Dependencies are inferred from the claim text.