Indolin-2-one derivatives

A compound represented by formula (I):

• wherein R1 represents a halogen atom;
• a lower alkyl group having 1-6 carbon atoms;
• a lower alkoxy group having 1-6 carbon atoms;
• a hydroxyl group;
• a nitro group;
• a trifluoromethyl group;
• a lower alkylthio group;
• a carbonyl group which is substituted by a hydrogen atom, a lower alkyl group, a carbocyclic aryl group having 6-14 carbon atoms, a lower alkoxy group or an amino group;
• a carboxyl group;
• a mercapto group;
• or a substituted or unsubstituted amino group;
• R2 represents a hydrogen atom;
• a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms;
• a substituted or unsubstituted lower alkenyl group having 2-6 carbon atoms;
• a substituted or unsubstituted lower alkynyl group having 2-6 carbon atoms;
• a substituted or unsubstituted lower alkoxy group having 1-6 carbon atoms;
• a substituted or unsubstituted carbonyl group which is substituted by a hydrogen atom, an alkyl group, a carbocyclic aryl group having 6-14 carbon atoms, a lower alkoxy group or an amino group;
• a substituted or unsubstituted aryl group having 6-14 carbon atoms;
• R3 represents a substituted or unsubstituted lower alkyl group having 1-6 carbon atoms;
• a substituted or unsubstituted cycloalkyl group having 3-8 carbon atoms;
• a substituted or unsubstituted aryl group having 6-14 carbon atoms;
• a menthyl group or an adamantyl group;
• R4 represents —OR5;
• —SR5;
• or —NR6R7, wherein R5 and R6 each represent a substituted or unsubstituted pyridyl group and R7 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms, a substituted or unsubstituted aryl group selected from the group consisting of phenyl and naphthyl, a lower alkoxy group or a substituted or unsubstituted amino group;
• X and Y, which may be the same or different, each represent —CH2—, —NH— or —O—;
• and
• n represents an integer of from 0 to 4;
• wherein the substituents in the definition of R1 to R7 represent a halogen atom;
• a lower alkyl group having 1-6 carbon atoms;
• a C3-C8 cycloalkyl group;
• a C6-C14 aryl group;
• a hydroxyl group;
• a lower alkoxy group having 1-6 carbon atoms;
• a C6-C14 aryloxy group;
• a lower alkylthio group;
• —CH(OR′)2, wherein R′ represents a lower alkyl group having 1-6 carbon atoms;
• a lower alkylcarbonyl group;
• a C6-C14 arylcarbonyl group;
• a carboxyl group;
• a lower alkoxycarbonyl group;
• an amino group which may be substituted with one to two methyl groups, an ethyl group or a trifluoromethylcarbonyl group;
• an imino group;
• —CR″(SR′)2, wherein R′ and R″ represent a lower alkyl group having 1-6 carbon atoms;
• a nitro group;
• a nitrile group;
• or a trifluoromethyl group;
• or a salt thereof or an optically active isomer thereof.