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US 6,207,835 B1Granted
Process for the preparation of arylmetal compounds and their reaction with electrophilic reagents
AssigneeMerck KGaA
InventorsVolker Reiffenrath, Hans Christian Stiasny
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Abstract
Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.
Claims16
A process for the preparation of an arylmetal compound comprising:
- deprotonating an aromatic compound having a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a base or by halogen-metal exchange of a haloaromatic using a metalating reagent,
- wherein said arylmetal compound is prepared in a continuous-flow reactor.
Dependencies are inferred from the claim text.