Process for producing piperidinecarboxylic acid amide derivatives
AssigneeAjinomoto Co., Inc.
InventorsIsao Arai, Takashi Yamamoto, Hirokazu Naora
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Abstract
A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence of an acid is provided. This process is an industrially excellent process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them.
Claims18
A process for producing piperidinecarboxylic acid amide derivatives of general formula (9):
- wherein X represents a heterocyclic ring which may have a substituent, an alkyl group having 1 to 10 carbon atoms, which may have a substituent, an alkoxyl group having 1 to 10 carbon atoms, which may have a substituent, a cycloalkyl group having 3 to 10 carbon atoms, which may have a substituent, an alkenyl group having 2 to 10 carbon atoms, which may have a substituent, or an aralkyl group having 7 to 12 carbon atoms and having an alkyl moiety having 1 to 6 carbon atoms, which may have a substituent, or phenyl group;
- Y represents hydrogen atom or a halogen atom;
- and Z represents an organic group of any of the following formulae (3), (4), (5), (6), (7) and (8),
- which comprises the step of reacting a 2-oxazoline compound of general formula (1):
- wherein X is as defined above with a piperidine derivative of general formula (2):
- wherein Y and Z are as defined above or a salt thereof in the presence of an acid.
Piperidinecarboxylic acid amide derivatives of general formula (10):
- wherein R1 represents methyl group or ethyl group;
- Y represents hydrogen atom or a halogen atom;
- and Z represents an organic group of any of the following formulae (3), (4), (5), (6), (7) and (8):
Dependencies are inferred from the claim text.