Macrocyclic compounds having nitrogen-containing linkages

A compound of the structure:

• wherein
• X is (—T—L)y
• y is 0-3
• each T is, independently, a single bond, a methylene group or a group having the structure
• —{[CR1R2]m—B—[CR1R2]n—[C(D)]p—E—}q—
• where:
• D is ═O, ═S, ═NR3;
• B and E, independently, are a single bond, CH═CH, C═C, O, S, NR3, or C6-C14 aryl;
• each R1, R2 and R3 is, independently, H, alkyl or haloalkyl having 1 to about 10 carbon atoms;
• alkenyl having 2 to about 10 carbon atoms;
• alkynyl having 2 to about 10 carbon atoms;
• or aryl having 6 to about 14 carbon atoms;
• m and n, independently, are zero to 5;
• p is zero or 1;
• q is 1 to about 10;
• and
• each L is, independently, H, C2-C10 alkyl or substituted alkyl, C2-C10 alkenyl or substituted alkenyl, C2-C10 alkynyl or substituted alkynyl, C4-C7 carbocyclic alkyl, alkenyl or alkynyl or substituted carbocyclic, or C6-C14 aryl or substituted aryl where the substituent groups are selected from hydroxyl, amino, alkoxy, alcohol, benzyl, phenyl, nitro, thiol, thioalkoxy, halogen, alkyl, aryl, alkenyl, or alkynyl groups, an ether having 2 to 10 carbon atoms and 1 to 4 oxygen or sulfur atoms, a nitrogen-containing heterocycle, a sulfur-containing heterocycle, an oxygen-containing heterocycle, a metal coordination group, a conjugate group, halogen, hydroxyl (OH), thiol (SH), keto (C═O), carboxyl (COOH), amide (CONR), amidine (C(═NH)NRR), guanidine (NHC(═NH)NRR), glutamyl, nitrate (ONO2), nitro (NO2), nitrile (CN), trifluoromethyl (CF3), trifluoromethoxy (OCF3), O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aralkyl, S-aralkyl, NH-aralkyl, amino (NH2), azido (N3), hydrazino (NHNH2), hydroxylamino (ONH2), sulfoxide (SO), sulfone (SO2), sulfide (S—), disulfide (S—S), silyl, a nucleosidic base or an amino acid side chain, wherein R is H or alkyl.