Activin receptor-like kinases, ALK-3 and ALK-6, and nucleic acids encoding them
AssigneeLudwig Institute for Cancer Research
InventorsKohei Miyazono, Peter ten Dijke, Petra Franzen, Hidetoshi Yamashita, Carl-Henrik Heldin
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Abstract
The invention relates to two members of the receptor family referred to as activin-like kinases. These two members are referred to as ALK-3 and ALK-6. The proteins have activin/TGF-β type I receptor functionality, and may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain V1B, and/or a GTKRYM sequence in subdomain VIII.
Claims5
An isolated nucleic acid molecule encoding an ALK-6 polypeptide comprising the amino acid sequence as whown in SEQ ID NO:
- 18.
An isolated and purified ALK-6 polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 18.
An isolated nucleic acid molecule encoding a human ALK-3 polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 6.
An isolated and purified human ALK-3 polypeptide comprising the amino acid sequence as shown in SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.