Prostate cell surface antigen-specific antibodies
AssigneeUniversity of Iowa Research Foundation
InventorsGeorge J. Weiner, Oskar W. Rokhlin, Michael B. Cohen
Life of this patent
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Abstract
Disclosed is an antibody that binds to a protein found on normal and cancerous prostate cells, but not found on nonprostate cells and a hybridoma that produces the antibody to the prostate-specific protein. Also disclosed are antibodies conjugated to labels or cytotoxic moieties.
Claims17
A hybridoma secreting monoclonal antibodies for prostate-derived cells, the hybridoma designated 5E10 corresponding to ATCC Accession NO. PTA-865.
A purified monoclonal antibody having specificity to an antigenic determinant on the surface of normal and cancerous prostate cells but not on the surface of non-prostatic tumor cells, peripheral blood cells, bone marrow hematopoietic and stromal fibroblast cells, or endothelial cells, wherein the antigenic determinant is a protein having a molecular weight of about 115 kDa as measured by SDS/PAGE, wherein the antibody is produced by a hybridoma deposited as ATCC Accession No. PTA-865.
A monoclonal antibody produced in the IgG1 class and which binds with at least one antigenic determinant of normal and cancerous prostate cells but not with a determinant of non-prostatic tumor cells, peripheral blood cells, bone marrow hematopoietic and stromal fibroblast cells, or endothelial cells, the antigenic determinant being a protein having a molecular weight of about 115 kDa as measured by SDS/PAGE, wherein the cancerous prostate cells are DU145, ND1, PC3, or a combination thereof.
Dependencies are inferred from the claim text.