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US 6,207,718 B1Granted
Pharmaceutical compositions containing hedgehog protein
AssigneeOntogeny, Inc.
InventorApollon Papadimitriou
Life of this patent
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Abstract
A composition of a hedgehog protein which includes as an additive cyclodextrin, a non-ionic detergent, an anionic saccharide and/or ionic salt containing zinc ions, magnesium ions, calcium ions and/or sulfate ions is especially stable at room temperature.
Claims19
A composition adapted for formulating unit dosage forms for administration to a patient wherein said composition comprises an aqueous solution containing a hedgehog protein;
- and an additive being present in an effective amount to stabilize said hedgehog protein in the aqueous solution, wherein said additive is selected from the group consisting of ionic salts, cyclodextrin, non-ionic detergent, anionic saccharide and mixtures thereof, said ionic salt containing an ion selected from the group consisting of zinc, sulfur, magnesium, calcium, arginine, argininium and mixtures thereof.
Dependencies are inferred from the claim text.