Non-steroidal ligands for the estrogen receptor

A compound of Formula I:

• wherein
• R1 is —(CH2)nCR5═CR6R7;
• —(CH2)mC(X)NR8R9;
• or
• R2 and R3 are independently H, —CH3, —OH, —OCH3, —OCH2CH3 or —CH2(CH3)2;
• R4 is —CN, —NO2, —CH3, —CH2CH3, —CH2CH2—Y or —Y;
• R5 and R6 are independently H, —C1-4alkyl, —C2-4alkenyl, —C2-4alkynyl, —X—C1-3alkyl, —X—C2-4alkenyl, —X—C2-4alkynyl or —Y;
• R7 is —CN, —C1-4alkyl—OH, —C(O)O(CH3)3, —C(O)NR10R11, —C(O)NR12R13, —C1-4alkyl—NR10R11, —C(O)R12, —C(O)OR12, —C(O)NR12OR13, —C(O)NHC(O)R12, —C(O)NHCH2R12, —C(NH2)(NOR12), —S(O)R12, —S(O)(O)(OR12), —S(O)(O)(NHCO2R12), PO3R12, —P(O)(NR12R13)(NR12R13), —P(O)(NR12R13)(OR14), —CONR12(CH2)q OCH3, —CONR12(CH2)qNR8R9 or oxadizole substituted with methyl;
• R8 and R9 are independently hydrogen, —C1-7alkyl, —C3-7cycloalkyl, —O—C1-7alkyl, —C1-7alkyl—Y or phenyl;
• R10 and R11 are independently methyl or ethyl or, taken together form a morpholino group bonded via its nitrogen atom;
• R12, R13 and R14 are independently H, —C1-12alkyl, —C2-12alkenyl, —C2-12alkynyl, —O—C1-12alkyl, —O—C2-12alkenyl, —O—C2-12alkynyl, —C3-7cycloalkyl, —C3-7cycloalkenyl, linear and cyclic heteroalkyl, aryl, heteroaryl or —Y;
• X is oxygen or sulfur;
• Y is a halogen;
• n is an integer selected from 0, 1 or 2;
• m is the integer 1 or 2;
• p is an integer selected from 1 to 4;
• and
• q is an integer from 1-12.