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US 6,207,700 B1Granted
Amide derivatives for antiangiogenic and/or antitumorigenic use
AssigneeVanderbilt University
InventorsAmit S. Kalgutkar, Lawrence J. Marnett
Life of this patent
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Abstract
A method of treating animals having cancer by administration of secondary amide derivatives of various COOH-containing drugs, such as COOH-containing NSAIDs, for instance, indomethacin.
Claims11
A method for cancer treatment in a warm blooded vertebrate animal, comprising administering to the animal a treatment effective amount sufficient to inhibit cancer of a carboxylic acid secondary amide derivative of a compound, wherein:
- (1) the secondary amide derivative (a) is selective for inhibition of cyclooxygenase-2, and (b) has an indole system, where the indole system has a nitrogen and the indole nitrogen is substituted with para-halobenzoyl, where the halo is selected from the group consisting of fluoro, chloro, and bromo, and
- (2) the compound (a) is a cyclooxygenase inhibitor but is absent selectivity for inhibition of cyclooxygenase-2 and (b) contains a carboxylic acid moiety or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.