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US 6,207,683 B1Granted
Benzocycloheptathiophene compounds
AssigneeBridge Pharma, Inc.
InventorsA. K. Gunnar Aberg, George E. Wright, Jan L. Chen
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Abstract
Disclosed are N-substituted hydroxyalkyl or carboxyalkyloxyalkyl analogs of 9- and/or 10-oxo-4Hbenzo[4,5]cycloheptal[1,2-b]thiophene compounds, or 9-OH and/or 10-OH-substituted analogs thereof, which possess antihistaminic and antiasthmatic properties with reduced sedative side effects. The optically active isomers and pharmaceutically acceptable salts thereof are also described. The compounds were also found to prevent smooth muscle hyperreactivity.
Claims20
A compound having the formula:
- including stereochemically isomeric forms thereof and pharmaceutically acceptable salts thereof, wherein:
- R is a member selected from the group consisting of hydroxyC2-6alkyl and carboxyC1-6alkyloxyC1-6alkyl, and
- —A—B— is a moiety having the formula
- —CO—CH2— (a)
- —CH2—CO— (b)
- —CH2—CH2— (c)
- —CHOH—CH2— (d)
- —CHOH—CHOH— (e)
- —CH2—CHOH— (f)
- or
- —CO—CO— (g).
8 more elements
Dependencies are inferred from the claim text.