Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids

A compound of formula I

• or an optionally stereoisomeric form of the compound of the formula I, or a physiologically tolerable salt of the foregoing, where:
• R1 is
• a radical of formula II
• and
• Q as part of the compound of formula I is
• structural moiety X
• R2 is
• (1) phenyl or
• (2) phenyl which is mono-, di-, or trisubstituted by
• 2.1 hydroxyl,
• 2.2 —O—R10, where R10 is
• 2.2.1 (C1-C6)-alkyl,
• 2.2.2 (C3-C6)-cycloalkyl,
• 2.2.3 benzyl, or
• 2.2.4 phenyl,
• 2.3 —COOH,
• 2.4 (C1-C6)-alkyl,
• 2.5 (C3-C6)-cycloalkyl-O-(C1-C4)-alkyl,
• 2.6 halogen,
• 2.7 —CN,
• 2.8 —CF3,
• 2.9 —O—C(O)—R10, where R10 is as defined above,
• 2.10 —O—C(O)-phenyl, mono- or disubstituted by R3,
• 2.11 —C(O)—O—R10, where R10 is as defined above,
• 2.12 —C(O)—NR11R12, where
• R11 and R12 may be identical or different and each is
• 2.12.1 a hydrogen atom,
• 2.12.2 (C1-C4)-alkyl,
• 2.12.3 benzyl, or
• 2.13 —NR13R14, where
• R13 is a hydrogen atom or (C1-C4)-alkyl, and R14 is
• 2.14.1 (C1-C4)-alkyl,
• 2.14.2 benzyl,
• 2.14.3 —C(O)—R10, or
• 2.14.4 —C(O)—O—R10, and R10 is as defined above;
• R6, R7, and R8 are identical or different, and each is
• (1) a hydrogen atom, or
• (2) has the meaning of R2 under items 2.1 to 2.12, and
• n is zero, 1, or 2, and m is zero, 1, or 2, such that the sum of n and m is 1, 2, or 3;
• X is
• (1) a covalent bond,
• (2) —O—,
• (3) —S—,
• (4) —S(O)—,
• (5) —S(O)2—,
• (6) —C(O)—, or
• (7) —C(OH)—;
• Y is
• (1) —O— or
• (2) —S—;
• A is HO—NH—C(O)— or HO—C(O)—;
• and
• B is
• (1) —(CH2)q—, where q is zero, 1, 2, 3 or 4, or
• (2) —CH═CH—.