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US 6,207,666 B1Granted
Method for treating a patient having precancerous lesion with 4-phenylphthalazine derivatives
AssigneeCell Pathways, Inc.
InventorsGary Piazza, Rifat Pamukcu
Life of this patent
Estimating the term…
Abstract
Derivatives of 4-phenylphthalazine are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
Claims23
A method of treating a patient in need of treatment having precancerous lesions sensitive to a compound of formula I, comprising administering to the patient a pharmacologically effective amount of a compound of formula I:
- wherein X stands for NH or O;
- R1 is selected from an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a halogen atom, an alkoxycarbonyl group having 2 to 6 total carbon atoms, a carboxyl group, a cyano group, an alkylcarbonyl group having 2 to 4 total carbon atoms, a hydroxyl group and a trifluoromethyl group;
- R2 and R3, which may be identical or different (may also be the same as or different from R1), each is selected from an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a halogen atom, an alkoxycarbonyl group having 2 to 6 total carbon atoms, a carboxyl group, an alkylcarbony group having 2 to 4 total carbon atoms, a hydroxyl group and a trifluoromethyl group;
- and
- each of l, m and n is an integer of zero to 3 (provided that l=1 to 3 and m=n=zero when X is O, and the case where l=m=n=zero is excluded when X is NH), each plural number of R1, R2 and R3 being identical or different when the integers l, m and n are two or more.
2 more elements
A method for inhibiting the growth of neoplastic cells sensitive to compound of formula I, comprising exposing said cells to an effective amount of a compound of formula:
- wherein X stands for NH or O;
- R1 is selected from an-alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a halogen atom, an alkoxycarbonyl group having 2 to 6 total carbon atoms, a carboxyl group, a cyano group, an alkylcarbonyl group having 2 to 4 total carbon atoms, a hydroxyl group and a trifluoromethyl group;
- R2 and R3, which may be identical or different (may also be the same as or different from R1), each is selected from an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a halogen atom, an alkoxycarbonyl group having 2 to 6 total carbon atoms, a carboxyl group, an alkylcarbony group having 2 to 4 total carbon atoms, a hydroxyl group and a trifluoromethyl group;
- and
- each of l, m and n is an integer of zero to 3 (provided that l=1 to 3 and m=n=zero when X is O, and the case where l=m=n=zero is excluded when X is NH), each plural number of R1, R2 and R3 being identical or different when the integers l, m and n are two or more.
2 more elements
Dependencies are inferred from the claim text.