Premixed formulation of piperacillin sodium and tazobactam sodium injection
AssigneeBaxter International Inc.
InventorsStacey S. Thompson, Rao Chilamkurti, Mary Samuel, Norma Stephens
Life of this patent
Estimating the term…
Abstract
The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (−20° C. or lower), or a refrigerated shelf life of up to 14 days at about 5° C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.
Claims42
A pharmaceutical composition suitable for administration parenterally, comprising a buffered solution having an effective amount of piperacillin and a pH adjusted to be in the range of from about 6.1 to about 6.9.
A process of making a pharmaceutical piperacillin composition having a refrigerated shelf life in excess of 7 days, comprising the steps of:
- a. dissolving an effective amount of piperacillin into a suitable liquid forming a premixed solution;
- b. adjusting the pH of the premixed solution to a range of from about 6.1 to about 6.9;
- c. filling suitable containers with the premixed solution;
- and
- d. storing the containers of premixed solution in a suitable atmosphere at about 5° C. ±3° C.
Dependencies are inferred from the claim text.