Texaphyrin conjugates and uses thereof

A texaphyrin-chemotherapeutic agent conjugate represented by Formula (A) or (B):

• wherein,
• Z is zero or an integer less than or equal to 5;
• M is hydrogen, a divalent metal cation or a trivalent metal cation;
• R1-R4 and R6-R9 are independently hydrogen, halide other than iodide, hydroxyl, alkyl, alkenyl, aryl, haloalkyl other than iodoalkyl, nitro, formyl, acyl, hydroxyalkyl, alkoxy, hydroxyalkoxy, saccharide, aminoalkyl, aminoalkoxy, carboxy, carboxyalkyl, carboxyamide, carboxyamidealkyl, a catalytic group, a couple to a catalytic group, a chemotherapeutic agent, a couple to a chemotherapeutic agent, a platinum(II) metal chelating site, a couple to a platinum(II) metal chelating site, a platinum(IV) metal chelating site, a couple to a platinum(IV) metal chelating site, a platinum(II) metal chelating site complexed with platinum(II), a couple to a platinum(II) metal chelating site complexed with platinum(II), a platinum(IV) metal chelating site complexed with platinum(IV), or a couple to a platinum(IV) metal chelating site complexed with platinum(IV);
• R5 and R10-R12 are independently hydrogen, alkyl, alkenyl, aryl, halide other than iodide, hydroxyalkyl, alkoxy, hydroxyalkoxy, aminoalkyl, aminoalkoxy, carboxyalkyl or carboxyamidealkyl, with the proviso that:
• where R5 is sterically larger than hydrogen or methyl, R6 is hydrogen, methyl, methoxy or halide other than iodide,
• where R6 is sterically larger than hydrogen or methyl, R5 is hydrogen, methyl, methoxy or halide other than iodide,
• where R9 is sterically larger than hydrogen or methyl, R10 is hydrogen, methyl, methoxy or halide other than iodide, and
• where R10 is sterically larger than hydrogen or methyl, R9 is hydrogen, methyl, methoxy or halide other than iodide;
• R13 is selected from alkyl, alkenyl, alkoxy or hydroxyalkyl having up to about three carbon atoms and having rotational flexibility around a first-bound carbon atom,
• or a pharmaceutically acceptable salt, ester or apical ligand thereof,
• with the proviso that at least one of R1-R4 or R6-R9 is a chemotherapeutic agent, a couple to a chemotherapeutic agent, a platinum(II) metal chelating site, a couple to a platinum(II) metal chelating site, a platinum(IV) metal chelating site, a couple to a platinum(IV) metal chelating site, a platinum(II) metal chelating site complexed with platinum(II), a couple to a platinum(II) metal chelating site complexed with platinum(II), a platinum(IV) metal chelating site complexed with platinum(IV), or a couple to a platinum(IV) metal chelating site complexed with platinum(IV), with the proviso that the chemotherapeutic agent is not a biomolecule, an antibody, a nucleotide, an oligonucleotide, a peptide, a protein, a steroid, a hormone or hormone mimic, a sappphyrin, or a rubyrin.