Preservation of tissue during removal storage and implantation
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsJames W. Simpkins, Pattie S. Green, Kelly E. Gridley
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Abstract
A method is provided for preserving tissues during removal, storage and implantation into a subject by enhancing cell viability in a population of graft cells during the transplantation procedure. The method includes selecting an effective dose of a polycylic phenolic compound in a physiologically acceptable formulation and exposing at least the population of graft cells to the formulation containing the compound within a time that is effectively proximate to the transplantation procedure so as to confer cytoprotection on the population of graft cells.
Claims19
A method for enhancing cell viability in a population of graft cells during a transplantation procedure, comprising:
- (a) selecting an effective dose of a polycyclic phenolic compound in a physiologically acceptable formulation;
- (b) exposing the population of graft cells to the formulation containing the compound within a time that is effectively proximate to the transplantation procedure:
- and
- (c) conferring cytoprotection on the population of graft cells.
A method of optimizing incorporation of graft cells into a recipient subject comprising;
- (a) selecting an effective dose of a polycyclic phenolic compound in a physiological acceptable formulation;
- and
- (b) administering the compound to at least one of;
- the donor of the graft cells at an effective time prior to removal of the graft cells;
- the ex vivo storage medium for the graft cells;
- and the recipient subject at an effective time prior to receipt of the cells.
Dependencies are inferred from the claim text.