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US 6,207,655 B1Granted
Bis-phosphonate confugates with alkylating moieties having antitumor activity
AssigneeNovuspharma S.p.A.
InventorsValeria Livi, Silvano Spinelli, Marco Conti, Simonetta D'Alo', Ernesto Menta
Life of this patent
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Abstract
The present invention relates to conjugates of 3-carboxy-4,4′-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
Claims11
A compound of the general formula (I):
- wherein:
- R, R1 and R2 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl, which can be linear or branched, with the proviso that R1 cannot be tert-butyl;
- X is chlorine, bromine or iodine;
- enantiomers, racemates, diastereoisomers and mixtures thereof, as well as salts thereof with pharmaceutically acceptable bases.
1 more element
Dependencies are inferred from the claim text.