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US 6,207,649 B1Granted
Nucleoside analogs and uses in treating disease
AssigneeLipitek International, Inc.
InventorsAlexander L Weis, Kirupathevy Pulenthiran
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Abstract
The invention relates to pharmaceutical compositions of nucleoside dimers containing an L-sugar in at least one of the nucleosides.
Claims12
A pharmaceutical composition comprised of a nucleoside dimer having the formula:
- R1—X—R2
- wherein X is a moiety PO4 or S═PO3;
- wherein R1 and R2 are the same or different nucleosides;
- wherein R1 and R2 are selected from the group consisting of β-D-deoxyfluorouridine, α-L-deoxyfluorouridine, β-L-deoxyfluorouridine, α-L-deoxycytidine, β-L-deoxycytidine, β-L-deoxyuridine, β-L-deoxyguanosine, β-L-deoxyadenosine, α-L-deoxyadenosine and nitrobenzylthionosine;
- and
- wherein R1 and R2 are attached to X through —OH groups.
3 more elements
A pharmaceutical composition of a nucleoside dimer comprising:
- β-D-deoxyfluorouridine, β-L-deoxyadenosine, and a suitable moiety for linking the two said nucleosides selected from the group consisting of PO4 or S═PO3.
Dependencies are inferred from the claim text.