Treatment of partial growth hormone insensitivity syndrome

A method for increasing the growth rate of a human patient with non-GH-deficient short stature but not Laron syndrome wherein said patient has a heterogeneous growth hormone receptor (GHR) gene defect, comprising detecting whether the patient has a height less than about −2 standard deviations below normal for age and sex, has a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, has a serum level of IGF-I that is below normal mean levels, and has a mean or maximum stimulated serum level of growth hormone that is at least normal, and, if so, administering an effective amount of growth hormone that increases the growth rate of the patient to said patient.

A method for increasing the growth rate of a human patient with non-GH-deficient short stature but not Laron syndrome wherein said patient has a heterogeneous growth hormone receptor (GHR) gene defect, comprising detecting whether the patient has a height less than about −2 standard deviations below normal for age and sex, has a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, has a serum level of IGF-I that is below normal levels, and has a mean or maximum stimulated serum level of growth hormone that is at least normal, and, if so, administering an effective amount of IGF-I to said patient.

A method for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome, comprising administering amounts of IGF-I and growth hormone that increases the growth rate of the patient to said patient which amounts are effective in combination, whereby said patient has a height less than about −2 standard deviations below normal for age and sex, has a serum level of high-affinity growth hormone binding protein that is at least 2 standard deviations below normal levels, has a serum level of IGF-1 that is below normal mean levels, and has a mean or maximum stimulated serum level of growth hormone that is at least normal, wherein the patient has a heterogeneous growth hormone receptor (GHR) gene defect and does not have Laron syndrome.

A method for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome whereby said patient has a heterogeneous GHR gene defect comprising administering an effective amount of growth hormone that increases the growth rate of the patient to said patient.

A method for increasing the growth rate of a human patient having partial growth hormone insensitivity syndrome whereby said patient has a heterogeneous gene defect comprising administering an effective amount of IGF-I to said patient.

A method for increasing the growth rate of a human patient with non-GH-deficient short stature but not Laron syndrome comprising detecting whether the patient has a heterogeneous GHR gene defect, and if so, administering an effective amount of growth hormone that increases the growth rate of the patient to said patient.

A method for increasing the growth rate of a human patient with non-GH-deficient short stature but not Laron syndrome comprising detecting whether the patient has a heterogeneous GHR gene defect, and if so, administering an effective amount of IGF-I to said patient.