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US 6,207,427 B1Granted
Method for producing optically active compound
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsShin-ichi Hashimoto, Ryoichi Katsumata
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Abstract
The present invention provides a method for industrially advantageously producing (S)-4-hydroxy-2-ketoglutaric acid and for producing compounds which are formed by biosynthesis from the precursor (S)-4-hydroxy-2-ketoglutaric acid, for example, for producing the compounds (2S,4S)-4-hydroxy-L-glutamic acid and (2S,4S)-4-hydroxy-L-proline, using a recombinant microorganism carrying a recombinant DNA harboring the DNA fragment encoding 4(S)-4-hydroxy-2-ketoglutaric acid aldolase gene.
Claims12
A method for producing an optically active compound, comprising:
- (a) allowing a recombinant microorganism carrying a recombinant DNA harboring (S)-4-hydroxy-2-ketoglutaric acid aldolase gene and having lipoate requirement, to act on sugar and glyoxylic acid in an aqueous medium, and
- (b) collecting optically active (S)-4-hydroxy-2-ketoglutaric acid or a compound from a precursor (S)-4-hydroxy -2-ketoglutaric acid, generated in the aqueous medium.
Dependencies are inferred from the claim text.