Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells
AssigneeThe Regents of the University of California
InventorsZhigang Weng, Owen N. Witte
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Abstract
A G protein-coupled receptor (GPCR) which is activated by oncogenes. The receptor is found predominantly in hematopoietic cells and tissues and functions as a tumor suppressor gene and induces cell cycle arrest. This receptor may play an important role in regulating the proliferation and differentiation of hematopoietic cells. Regulation of receptor activity has several therapeutic applications.
Claims6
An isolated polynucleotide having the nucleotide sequence shown in SEQ ID NO:
- 1 or 3.
An isolated, recombinant GPCR having the amino acid sequence shown in SEQ ID NO:
- 2 or 4.
An isolated polynucleotide which encodes the protein having the amino acid sequence shown in SEQ ID NO:
- 2.
An isolated polynucleotide which encodes the protein having the amino acid sequence shown in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.