Methods of controlling T lymphocyte mediated immune responses
AssigneeHRC Research and Development Limited Partnership
InventorHans Michael Dosch
Life of this patent
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Abstract
Methods and compositions are provided for preventing the development of a T cell mediated autoimmune disease such as Type I diabetes, in which susceptible subjects have T cells sensitized to a disease-related antigen. Subjects are treated by administration of the antigen or fragments thereof to prevent the expansion of the population of sensitized T cells. Alternatively, subjects are treated by administration of immunogenic compositions comprising a mimicry antigen or fragments thereof.
Claims9
A protein encoded by a nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:29, SEQ ID NO:30 and SEQ ID NO:31.
A protein consisting of the amino acid sequence of SEQ ID NO 41 or a peptide fragment of said protein including the amino acid sequence of SEQ ID NO 23.
A method for detecting a subject at risk for diabetes comprising obtaining a serum sample from said subject and detecting antibodies in said sample reactive against p69 protein with an immunoassay employing a protein or peptide selected from the group consisting of:
- (a) a protein consisting of the amino acid sequence of SEQ ID NO 41;
- and
- (b) a peptide fragment of said protein including the amino acid sequence of SEQ ID NO 23;
- an increased level of said antibodies over control values indicating that said subject is at risk for diabetes.
A method for detecting a subject at risk for diabetes comprising:
- obtaining a sample containing T lymphocytes from said subject;
- contacting the T lymphocytes, in the presence of an effective amount of interleukin 2, with a protein or peptide selected from the group consisting of:
- (a) a protein consisting of the amino acid sequence of SEQ ID NO 41;
- and
- (b) a peptide fragment of said protein including the amino acid sequence of SEQ ID NO 23;
- and detecting a proliferative response of said T lymphocytes to the protein or peptide, said proliferative response indicating that said subject is at risk for diabetes.
Dependencies are inferred from the claim text.