Method of detection of polymorphism and loss of heterozygosity in a lung tumor suppressor gene
AssigneeRoche Diagnostics GmbH
InventorIlse Wieland
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Abstract
The invention relates to a determination of a polymorphism or less of heterozygosity, by assaying a sample with one or both of SEQ ID NO: 1 and SEQ ID NO: 2. These oligonucleotides facilitate identification of polymorphisms and lack of heterozygosity at chromosomal location 5p15-q21. This region contains a tumor suppressor gene.
Claims8
A method for detection of a polymorphism or loss of heterozygosity located in chromosome region 5p15-q21, comprising contacting a sample with a first oligonucleotide having the nucleotide sequence of SEQ ID NO:
- 1, and a second oligonucleotide having the oligonucleotide sequence of SEQ ID NO:
- 2, and determining hybridization of said oligonucleotides to a nucleic acid molecule in said sample as a determination of a polymorphism or a loss of heterozygosity in said chromosome region.
Composition comprising each of(i) an oligonucleotide, the nucleotide sequence of which consists of SEQ ID NO:
- 1, and (ii) an oligonucleotide, the nucleotide sequence of which consists of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.