Process for making a particulate support matrix for making a rapidly dissolving dosage form

A process for producing a particulate support matrix for use in forming a pharmaceutical dosage form, comprising:

• providing an aqueous composition comprising:
• an aqueous medium,
• a support agent comprising an amount of a non-hydrolyzed gelatin component having a predetermined net charge, an amount of a hydrolyzed gelatin component having a predetermined net charge of the same sign as the non-hydrolyzed gelatin component, and a bulking agent and wherein the non-hydrolyzed gelatin component and the hydrolyzed gelatin component together comprise from about 2% to 35% of the Particulate support matrix and the bulking agent comprises from about 45% to 97% of the particulate support matrix, and wherein the hydrolyzed gelatin component has a solubility in aqueous solution greater than that of the non-hydrolyzed gelatin component, and
• a volatilizing agent;
• and
• introducing the aqueous composition as droplets into a drying chamber heated to a temperature sufficient to evaporate substantially all of the aqueous medium and volatilizing agent from the droplets leaving the support agent in a dried particulate form comprising the particulate support matrix and wherein the particulate support matrix is substantially completely disintegrable within less than about 20 seconds when introduced into an aqueous environment.

A process for producing a particulate support matrix for use in forming as pharmaceutical dosage form, comprising:

• providing an aqueous composition comprising:
• an aqueous medium,
• a support agent comprising an amount of a first gelatin component having a predetermined net charge, an amount of a second gelatin component having a predetermined net charge of the same sign as the first gelatin component, and a bulking agent and wherein the first gelatin component and the second gelatin component together comprise from about 2% to 35% of the particulate support matrix and the bulking agent comprises from about 45% to 97% of the particulate support matrix, and wherein the second gelatin component has a solubility in aqueous solution greater than that of the first gelatin component, and
• a volatilizing agent;
• and
• introducing the aqueous composition as droplets into a drying chamber heated to a temperature sufficient to evaporate substantially all of the aqueous medium and volatilizing agent from the droplets leaving the support agent in a dried particulate form comprising the particulate support matrix and wherein the particulate support matrix is substantially completely disintegrable within less than about 20 seconds when introduced into an aqueous environment.