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US 6,207,198 B1Granted
Composition containing an acid-labile omeprazole and process for its preparation
AssigneeSchwarz Pharma AG
InventorPawan Seth
Life of this patent
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Abstract
A composition, particularly adapted for oral administration, containing omeprazole, and a method for preparing the composition, are disclosed. The composition, being exempt of alkaline-reacting compounds, contains a core constituted of nuclei and said benzimidazole, the nuclei and benzimidazole being compressed together, an intermediate layer, and an enteric layer.
Claims29
A stable drug composition comprising:
- (a) a core containing an acid-labile omeprazole active principle, said core being constituted of pharmaceutically inert nuclei and said active ingredient compressed together, and said omeprazole active principle not being in the form of an alkaline salt;
- (b) an intermediate layer comprising at least one polymer selected from the group consisting of sugars, polyethyleneglycol, polyvinylpyrrolidone, poly(vinyl alcohol), hydroxypropylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, and mixtures thereof;
- and
- (c) an enteric layer, said composition exempt from alkaline-reacting compounds.
1 more element
A stable drug composition comprising:
- (a) a core containing an acid-labile omeprazole active principle, said core being constituted of pharmaceutically inert nuclei and said active ingredient compressed together, and said omeprazole active principle not being in the form of an alkaline salt;
- (b) an intermediate layer comprising at least one compound selected from the group consisting of polysorbate 80, sodium lauryl sulfate, talc, microcrystalline cellulose, colloidal silica, sodium stearylfumarate, magnesium stearate, titanium dioxide, silicon dioxide, and mixtures thereof;
- and
- (c) an enteric layer, said composition exempt from alkaline-reacting compounds.
1 more element
Dependencies are inferred from the claim text.