Transdermal drug delivery system
AssigneeStephen E. Feldman
InventorFrank C. Pellegrini
Life of this patent
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Abstract
There is disclosed a transdermal drug delivery system wherein a drug or therapeutic agent is encapsulated in a water soluble carbohydrate. The carbohydrate-encapsulated drug or therapeutic agent, in the form of finely divided particles, is suspended in a cyanoacrylate ester which is applied to the skin of a mammal. Moisture on the skin and contact with skin tissue causes the cyanoacrylate to polymerize and the moisture on the skin also dissolves the carbohydrate permitting the drug or therapeutic agent, over time, to enter the body system through the pores of the skin.
Claims43
A transdermal drug delivery system comprising:
- a drug or therapeutic agent encapsulated in a water soluble carbohydrate, said carbohydrate-encapsulated drug or therapeutic agent being suspended in a cyanoacrylate ester capable of polymerizing upon coming into contact with moisture or skin tissue.
A transdermal drug delivery system comprising:
- a drug or therapeutic agent encapsulated in a water soluble carbohydrate, said carbohydrate-encapsulated drug or therapeutic agent being in the form of finely divided micro-fine particles, said particles being suspended in a cyanoacrylate ester which is capable of polymerizing upon coming into contact with moisture or skin tissue, said drug or therapeutic agent being a member selected from the group consisting of antibiotics, antivirals, antifungals, antibacterials, analgesics and antiseptics, said carbohydrate is a monosaccharide or a disaccharide, and said cyanoacrylate ester has the formula:
- wherein R is an alkyl of 2-12 C atoms, an alkenyl of 5-10 C atoms, phenyl, substituted phenyl, 2-ethoxyethyl, and 3-methoxybutyl.
A transdermal drug delivery system comprising:
- a drug or therapeutic agent encapsulated in a water soluble carbohydrate, said carbohydrate-encapsulated drug or therapeutic agent being in the form of finely divided micro-fine particles having a diameter of from about 5 to about 50 millimicrons, said particles being suspended in a cyanoacrylate ester which is capable of polymerizing upon coming into contact with moisture or skin tissue, said drug or therapeutic agent being a member selected from the group consisting of antibiotics, antivirals, antifungals antibacterials, analgesics and antiseptics, said carbohydrate is a monosaccharide selected from the group consisting of glucose, mannose, galactose and fructose or a disaccharide selected from the group consisting of sucrose, lactose, maltose and cellobiose, and said cyanoacrylate ester has the formula:
- wherein R is an alkyl of 2-12 C atoms, an alkenyl of 5-10 C atoms, phenyl, substituted phenyl, 2-ethoxyethyl and 3-methoxybutyl, said drug or therapeutic agent being present in an amount of from about 5 to about 25% by weight of said carbohydrate and the weight ratio of said carbohydrate-encapsulated drug or therapeutic agent to said cyanoacrylate ester being about 1:5, said system optionally including a plasticizer or a polymerization inhibitor or both a plasticizer and a polymerization inhibitor.
A method for preparing a transdermal drug delivery system comprising:
- a) dissolving or suspending a drug or therapeutic agent in a molten, water soluble carbohydrate;
- b) cooling said molten carbohydrate to form a glass-like matrix in which said drug or therapeutic agent is encapsulated;
- c) pulverizing said glass-like matrix to obtain finely divided micro-fine particles having a diameter of from about 10 to about 400 millimicrons;
- and,
- d) suspending said particles in a cyanoacrylate ester capable of polymerizing upon coming into contact with moisture or skin tissue, said cyanoacrylate ester having the formula:
- wherein R is an alkyl of 2-12 C atoms, an alkenyl of 5-10 C atoms, phenyl, substituted phenyl, 2-ethoxyethyl and 3-methoxybutyl.
Dependencies are inferred from the claim text.