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US 6,207,188 B1Granted
Omeprazole sodium salt
AssigneeAstraZeneca AB
InventorsAnders Gustavsson, Kristina Kjellbom, Ingvar Ymén
Life of this patent
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Abstract
This invention relates to a novel form of the sodium salt of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, known under the generic name omeprazole sodium salt. This invention also relates to processes for its preparation of omeprazole sodium form B which is thermodynamically stable, as well as pharmaceutical compositions containing it and its use in the treatment of gastrointestinal disorders.
Claims9
Omeprazole sodium form B having an X-ray powder diffraction pattern exhibiting substantially the following d-values and intensities:
- d-value/A° relative intensity 9.8 vs 7.8 vw 6.7 s 6.5 s 6.2 vw 5.9 m 5.8 vw 5.4 w 5.1 w 4.6 m 4.5 m 4.3 s 4.1 m 3.96 m 3.92 m 3.71 s 3.60 w 3.43 vw 3.37 w 3.25 vw 3.17 vw 3.14 w 3.12 m 3.05 w 2.99 w 2.98 m 2.91 m 2.89 m 2.79 vw 2.62 vw 2.59 vw 2.50 vw 2.45 vw 2.40 vw 2.37 vw 2.28 vw.
Dependencies are inferred from the claim text.