Conjugate vaccine for nontypeable Haemophilus influenzae
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsXin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins
Life of this patent
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Abstract
A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
Claims20
A conjugate vaccine for nontypeable Haemophilus influenzae (NTHi), comprising lipooligosaccharide (LOS) from which esterified fatty acids have been removed from lipid A to form detoxified LOS (dLOS), and an immunogenic carrier covalently linked thereto.
A conjugate vaccine for nontypeable Haemophilus influenzae (NTHi), comprising lipooligosaccharide (LOS) from which esterified fatty acids have been removed from lipid A to form detoxified LOS (dLOS), and an immunogenic carrier covalently linked thereto via a linker.
Isolated nontypeable Haemophilus influenzae (NTHi) lipooligosaccharide (LOS) detoxified by removal of ester-linked fatty acids from lipid A to form detoxified LOS (dLOS) coniugated to a carrier.
Dependencies are inferred from the claim text.