Aqueous solution of t-PA
AssigneeMitsui Chemicals, Inc.
InventorsYukio Shimazaki, Nobuhiro Kawashima, Miki Suzuki, Yasuhito Tanaka, Ryo Tanaka, Kiyoshi Sakai, Hisahiro Ishiwari
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Abstract
Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.
Claims1
The method for increasing the solubility of t-PA, in an aqueous solution at a pH of 5 to 9, said t-PA having a solubility of at most 2.0 mg/ml measured at a pH of about 7.3 in 1/15 M phosphate buffer said method comprising adding an anionic polymer or a salt thereof to said solution.
Dependencies are inferred from the claim text.