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AssigneesRoche Diagnostics GmbH, Bundesrepublik Deutschland, vertreten durch den Bundesminister fur Gesundheit
InventorsReinhard Kurth, Michael Baier, Norbert Bannert, Karin Metzner, Albrecht Werner, Kurt Lang
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A nucleic acid which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein in the region coding for the said polypeptide the said nucleic acid a)corresponds to the DNA sequence of nucleotides 54-1175 from SEQ ID NO:1 or to its complementary strand, b) hybridizes with the DNA of nucleotide sequence 54-785 from SEQ ID NO:1 under stringent conditions, c) hybridizes with the DNA of nucleotide sequence 786-1175 from SEQ ID NO:1 under stringent conditions and at the 5′ end begins with nucleotides 756-785 from SEQ ID NO:1 or a part thereof which codes for part of the sequence of amino acids 235-244 from SEQ ID NO:1 or d) it is a nucleic acid sequence which would hybridize under stringent conditions with the nucleic acid sequences defined by a) or b) without the degeneracy of the genetic code, codes for proteins with improved interleukin-16 activity.
An isolated nucleic acid encoding a polypeptide with interleukin-16 activity, wherein said nucleic acid can be expressed in a prokaryotic or eukaryotic host cell, comprising a nucleic acid sequence selected from the group consisting of
A purified polypeptide with interleukin-16 activity, wherein the polypeptide can be expressed using a nucleic acid comprising a nucleic acid sequence selected from the group consisting of
Dependencies are inferred from the claim text.