Tricalcium phosphate-containing biocement pastes comprising cohesion promoters
AssigneeMerck Patent GmbH
InventorsFerdinand C. M. Driessens, Robert Wenz
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Abstract
The invention relates to biocement pastes based on tricalcium phosphate and materials which are suitable for preventing or reducing the tendencies of the settable pastes to disintegrate and for improving their cohesion properties, with the result that improved processing of said pastes in the preparation of synthetic bone cements is ensured.
Claims17
A biocement paste comprising:
- a) tricalcium phosphate,
- b) at least one further calcium phosphate-containing compound,
- c) a cohesion promoter, and
- d) a setting accelerator,
- wherein components a) and b) form a cement powder, and components c) and d) are in an aqueous solution,
- wherein said cement powder is mixed with said aqueous solution to form said biocement paste,
- and wherein said setting accelerator is Na2HPO4, NaH2PO4, KH2PO4, K2HPO4, or mixtures thereof, in a concentration of 0.5-5% (wt/wt), based on the liquid phase before the paste is formed.
A process for the preparation of a calcium phosphate-containing cement paste having improved cohesion properties, comprising mixing a cement powder which contains tricalcium phosphate and at least one further calcium phosphate-containing compound with an aqueous solution of a cohesion promoter in a concentration of 0.1 to 5% (wt/wt) based on the liquid phase, and a setting accelerator in a concentration of 0.2-5% (wt/wt), based on the liquid phase.
In a processible, settable biocement paste, suitable for the preparation of biocompatible bone cement, the improvement wherein said biocement is formed by mixing together cement powder comprising tricalcium phosphate and at least one further calcium phosphate-containing compound, and an aqueous solution containing a cohesion promoter and a setting accelerator, wherein said setting accelerator is Na2HPO4, NaH2PO4, KH2PO4, K2HPO4, or mixtures thereof, in a concentration of 0.5-5% (wt/wt), based on the liquid phase before the paste is formed.
A kit for the preparation of a biocement paste, comprising a cement powder comprising tricalcium phosphate and at least one further calcium phosphate-containing compound, and an aqueous solution containing a cohesion promoter and a setting accelerator, wherein said setting accelerator is Na2HPO4, NaH2PO4, KH2PO4, K2HPO4, or mixtures thereof, in a concentration of 0.5-5% (wt/wt), based on the liquid phase before the paste is formed.
Dependencies are inferred from the claim text.