Composition and method for forming biodegradable implants in situ and uses of these implants
AssigneeBen-Gurion University of the Negev
InventorsRom Eliaz, Joseph Kost
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Abstract
The invention discloses a composition having a mixture of a pharmaceutically, medically or veterinarily acceptable polymer, preferable a poly (lactic-co-glycolic acid) copolymer (PLGA) containing between about 10 and 100 wt. % lactic acid (LA) units, preferably between about 50 and 90 wt. % LA units, and α-(tetrahydrofuranyl)-ω-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol). Methods of forming solid implants in situ in an animal body, said implants optionally comprising a drug or other biologically active agent, as well as the use of the compositions of the invention in the treatment of animal bodies, are also disclosed.
Claims26
A composition comprising a mixture of
- a polymer which is poly(lactic-co-glycolic acid) copolymer (PLGA) containing between about 10 and 100 wt. % lactic acid (LA) units, and
- α-(tetrahydrofuranyl)-ω-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol).
A method for producing a solid implant in situ in an animal body, including man, comprising the steps of:
- a—dissolving a polymer which is poly(lactic-co-glycolic acid) copolymer (PLGA) containing from about 10-100 wt. % lactic acid (LA) units, in α-(tetrahydrofuranyl)-ω-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol) to form a liquid;
- b—administering a suitable amount of said liquid to an animal, including man, in need thereof, and
- c—allowing said glycofurol to dissipate in said animal to leave a solid implant composed of a PLGA polymeric matrix.
A method of treating an animal, including man, in need of a prosthetic or orthodontic implant comprising the steps of:
- a—dissolving a polymer which is poly(lactic-co-glycolic acid) copolymer (PLGA) containing between about 10-100 wt. % lactic acid (LA) units, in α-(tetrahydrofuranyl)-ω-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol) to form a liquid;
- b—administering said liquid to an animal body;
- and
- c—allowing said glycofurol to dissipate to leave a solid implant in said animal body.
A method of treating an animal, including man, in need of controlled or sustained release of a drug or other biologically active agent, comprising the steps of:
- a—dissolving a polymer which is poly(lactic-co-glycolic acid) copolymer (PLGA) containing between about 10-100 wt. % lactic acid (LA) units, and dissolving, dispersing or suspending said drug or other biologically active agent, in α-(tetrahydrofuranyl)-ω-hydroxypoly(oxy-1,2-ethandiyl) (glycofurol) to form a liquid, wherein said dissolving, dispersing or suspending of said drug or other biologically active agent may take place previously, concurrently, or subsequently to said dissolving of said polymer;
- b—administering said liquid to an animal body;
- and
- c—allowing said glycofurol to dissipate to leave a solid, controlled-release device in said animal body.
Dependencies are inferred from the claim text.