Implantable system with drug-eluting cells for on-demand local drug delivery
AssigneeMedtronic, Inc.
InventorsOrhan Soykan, Maura G. Donovan
Life of this patent
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Abstract
An implantable system that includes a carrier and eukaryotic cells, which produce and release a therapeutic agent, and a stimulating element for stimulating the release of the therapeutic agent. The system can also include a sensing element for monitoring a physiological condition and triggering the stimulating element to stimulate the delivery device to release the therapeutic agent. Alternatively, the patient in which the system is implanted can activate the stimulating element to release the therapeutic agent.
Claims37
An implantable system comprising:
- (a) a delivery device comprising a carrier and eukaryotic cells that produce at least one therapeutic agent;
- (b) a stimulating element operatively coupled to the delivery device for stimulating the release of the therapeutic agent from the delivery device;
- and
- (c) a sensing element for monitoring at least one physiological property of a patient in which the system is implanted and communicating with the stimulating element to stimulate the release of the therapeutic agent from the delivery device.
A method of local delivery of a therapeutic agent to a patient, the method comprising:
- (a) providing an implantable system comprising:
- (i) a delivery device comprising a carrier and eukaryotic cells that produce at least one therapeutic agent;
- (ii) a stimulating element operatively coupled to the delivery device for stimulating the release of the therapeutic agent from the delivery device;
- and
- (iii) a sensing element for monitoring at least one physiological property of a patient in which the system is implanted and communicating with the stimulating element to stimulate the release of the therapeutic agent from the delivery device;
- and
- (b) implanting the implantable system into the body of a patient;
- wherein the therapeutic agent is released from the delivery device when the sensing element detects a predetermined level of a physiological property and communicates with the stimulating element to trigger the release of the therapeutic agent.
An implantable system comprising:
- (a) a delivery device comprising an intraluminal stent carrier having a lumen-wall contacting surface and a lumen-exposed surface, a polymer composition covering at least a portion of the stent carrier, and eukaryotic cells residing with the polymer composition and being adapted to produce at least one therapeutic agent;
- (b) a stimulating element operatively coupled to the delivery device for stimulating
- (b) a stimulating element operatively coupled to the delivery device for stimulating the release of the therapeutic agent from the delivery device;
- and
- (c) a sensing element for monitoring at least one physiological property of a patient in which the system is implanted and communicating with the stimulating element to stimulate the release of the therapeutic agent from the delivery device.
A method of local delivery of a therapeutic agent to a patient, the method comprising:
- (a) providing an implantable system comprising:
- (i) a delivery device comprising a carrier and eukaryotic cells that produce at least one therapeutic agent;
- (ii) a stimulating element operatively coupled to the delivery device for stimulating the release of the therapeutic agent from the delivery device;
- and
- (iii) a sensing element for monitoring at least one physiological property of a patient in which the system is implanted and communicating with the stimulating element to stimulate the release of the therapeutic agent from the delivery device;
- and
- (b) implanting the implantable system into the body of a patient;
- wherein the therapeutic agent is released from the delivery device when the sensing element detects a predetermined level of a physiological property and communicates with the stimulating element to trigger the release of the therapeutic agent and wherein the sensing element is selected from a group consisting of a blood gas sensor, a pH sensor, and a blood flow sensor.
Dependencies are inferred from the claim text.