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US 6,204,371 B1Granted
Compositions and methods for the treatment and diagnosis of immune disorders
AssigneeMillennium Pharmaceuticals, Inc.
InventorDouglas Adam Levinson
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AssigneeMillennium Pharmaceuticals, Inc.
InventorDouglas Adam Levinson
Estimating the term…
The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials.
An isolated nucleic acid molecule which contains:
An isolated nucleic acid molecule containing nucleotides 40 through 882, as depicted in FIG. 17 and SEQ ID NO:22.
An isolated nucleic acid molecule containing nucleotides 1 through 903, as depicted in FIG. 24 (SEQ ID NO:37).
An isolated nucleic acid molecule containing a nucleotide sequence which encodes at least one of the following peptide domains depicted in FIG. 17 (SEQ ID NO:
An isolated nucleic acid molecule containing a nucleotide sequence which encodes at least one of the following peptide domains depicted in FIG. 24 (SEQ JD NO:24):
An isolated nucleic acid molecule containing a nucleotide sequence which encodes a polypeptide depicted in FIG. 17 (SEQ ID NO:
An isolated nucleic acid molecule containing a nucleotide sequence which encodes a polypeptide depicted in FIG. 24 (SEQ. ID NO:24), wherein the polypeptide lacks at least one but not all of the following peptide domains depicted in FIG. 24 (SEQ ID NO:24):
A nucleic acid molecule comprising a nucleotide sequence which encodes a fusion polypeptide comprising, first, at least one of the following peptide domains depicted in FIG. 17 (SEQ ID NO:10):
A nucleic acid molecule comprising a nucleotide sequence which encodes a fusion polypeptide comprising, first, at least one of the following peptide domains depicted in FIG. 24 (SEQ ID NO:
An isolated nucleic acid molecule containing a nucleotide sequence encoding the mature extracellular domain of the polypeptide depicted in FIG. 17 (SEQ ID NO:
An isolated nucleic acid molecule containing a nucleotide sequence encoding amino acid residues 21 to 200 depicted in FIG. 17 (SEQ ID NO:
An isolated nucleic acid molecule containing nucleotides 61 to 600 as depicted in FIG. 17 (SEQ ID NO:
An isolated nucleic acid molecule containing a nucleotide sequence encoding the mature extracellular domain of the polypeptide depicted in FIG. 24 (SEQ ID NO:24).
An isolated nucleic acid molecule containing a nucleotide sequence encoding amino acid residues 21 to 200 depicted in FIG. 24 (SEQ ID NO:24).
An isolated nucleic acid molecule containing nucleotides 61 to 600 as depicted in FIG. 24 (SEQ ID NO:23).
An isolated nucleic acid molecule containing a nucleotide sequence encoding the Ig type variable set domain of the polypeptide depicted in FIG. 24 (SEQ ID NO:24).
Dependencies are inferred from the claim text.