MN gene and protein
AssigneeInstitute of Virology of the Slovak Academy of Sciences
InventorsJan Zavada, Silvia Pastorekova, Jaromir Pastorek
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AssigneeInstitute of Virology of the Slovak Academy of Sciences
InventorsJan Zavada, Silvia Pastorekova, Jaromir Pastorek
Estimating the term…
A new gene—MN—and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and recombinant proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity, and the invention concerns methods and compositions for detecting and/or quantitating MN antigen and/or MN-specific antibodies in vertebrate samples that are diagnostic/prognostic for neoplastic and pre-neoplastic disease. Test kits embodying the immunoassays of this invention are provided. MN-specific antibodies are disclosed that can be used diagnostically/prognostically, therapeutically, for imaging, and/or for affinity purification of MN proteins/polypeptides. Also provided are nucleic acid probes for the MN gene as well as test kits comprising said probes. The invention also concerns vaccines comprising MN proteins/polypeptides which are effective to immunize a vertebrate against neoplastic diseases associated with the expression of MN proteins. The invention still further concerns antisense nucleic acid sequences that can be used to inhibit MN gene expression, and polymerase chain reaction (PCR) assays to detect genetic rearrangements.
An isolated and purified MN nucleic acid, comprising at least 16 nucleotides to about 10,898 nucleotides, which comprises a nucleotide sequence which is selected from the group consisting of:
An isolated and purified MN nucleic acid comprising at least 16 nucleotides and at most about 1522 nucleotides, that encodes an MN protein or an MN polypeptide, which comprises a nucleotide sequence which is selected from the group consisting of:
An isolated MN nucleic acid, comprising at least 50 nucleotides to about 10,898 nucleotides, which comprises a nucleotide sequence which is selected from the group consisting of:
Dependencies are inferred from the claim text.