Hybrid cytokines
AssigneeFred Hutchinson Research Center
InventorsGeorge J. Todaro, Timothy M. Rose
Life of this patent
Estimating the term…
Abstract
Hybrid cytokines containing four helical regions, each of which is derived from a corresponding α-helical region in leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF), interleukin-6 (IL-6) or oncostatin-M (OSM) are disclosed. These hybrid cytokines may further contain linking regions also derived from corresponding linking regions in these factors. The hybrid cytokines offer a unique spectrum of activities useful in treating conditions for which the native cytokines are useful or in treating conditions characterized by an excess of the native cytokines.
Claims16
A hybrid cytokine comprising a first, second, third and fourth α-helical region wherein each of said first, second, third and fourth α-helical regions is derived from the corresponding α-helical region of a factor selected from the group consisting of leukemia inhibitory factor (LIF or L), granulocyte-colony stimulating factor (G-CSF or G), interleukin-6 (IL-6 or I), and oncostatin-M (OSM or O);
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- wherein at least one said α-helical region of said cytokine is derived from a factor different from that from which at least one additional region of said cytokine is derived.
Dependencies are inferred from the claim text.