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US 6,204,308 B1Granted
Organic compounds
AssigneeNovartis AG
InventorsMichael Ausborn, David Bodmer, Oskar Nagele, Laurent Marchal
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Abstract
An emulsion-based method of microencapsulating an active agent wherein a water-in-oil emulsion, containing a matrix-forming polymer and an active agent, is dispersed in an aqueous external phase to form a microencapsulated product.
Claims9
A method of preparing a microencapsulated pharmaceutically active agent, the method comprising the steps of
- a) dispersing an aqueous solution of a pharmaceutically active agent in a solution comprising an organic polymer solvent and a polymer dissolved therein, to form a water-in-oil primary emulsion,
- b) mixing the primary emulsion with an aqueous external phase comprising water and a surfactant;
- and
- c) dispersing the primary emulsion in the aqueous external phase to produce a product comprising the microencapsulated pharmaceutically active agent in a dispersed mixture,
- wherein the dispersing step c is performed before the polymer solvent can be extracted from the primary emulsion as a result of performing step b, and
- d) passing a current of N2 or air over the dispersed mixture.
3 more elements
Dependencies are inferred from the claim text.