Patient oxygenation using stabilized fluorocarbon emulsions
AssigneeAlliance Pharmaceutical Corp.
InventorsJeffry Greg Weers, David Henry Klein, Cindy Shizuko Johnson
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Abstract
Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluorocarbon or fluorocarbon mixture, in which the second fluorocarbon has a molecular weight greater than that of the first fluorocarbon and the second fluorocarbon includes a lipophilic moiety in its structure, whereby the second fluorocarbon serves to promote particle size stability in the emulsion while simultaneously providing favorably short organ retention times when administered to animals in vivo.
Claims4
A method for delivering oxygen using a stabilized emulsion to a patient in need thereof comprising the steps of;
- intravenously administering to said patient a therapeutically effective amount of a fluorocarbon emulsion comprising an emulsifying agent, a continuous aqueous phase and a discontinuous phase wherein said discontinuous phase comprises from about 60% to about 99.9% w/w of perfluorooctyl bromide and from about 0.1% to about 40% by weight of perfluorodecyl bromide.
Dependencies are inferred from the claim text.